Just started with my pen with this one.
Once my line work is down I went straight for the paint and started laying down my washes of color.
I went a bit more abstract with this one.
After laying down all my light and dark tone marks I follow up with laying down my flat colors on the skull and the spinal cord.
Now that those are done I move back in with my pen and sharpen lines out.
Finally I then take another color and put a little shadow down.
There you have it. On to the next one with a bit more movement.